Do you want to be “do not resuscitate?” Do you want to be DNR? If you are admitted to the hospital, they may talk to you about advanced directives, a living will, or a durable power of attorney for healthcare. These things vary from state to state. One of the things you may have to figure out is whether you want a "do not resuscitate" (DNR) order on your chart or not.
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Cardiac Arrest in the Hospital
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Intravitreal injections for Age related macular degeneration: what's the score?
1.75 million people in the US have exudative age related macular degeneration. For the past 10 years these patients have been going to their eye doctor every month for an injection into the eye. It must be a worthwhile treatment to keep people coming back for an injection into their eye. It got me thinking about what the true evidence is behind these treatments.
Once the diagnosis and outcome were identified, I picked the treatments. There are three anti-VEGF molecules used for AMD. Lucentis is a very common VEGF inhibtior with a good deal of evidence in the literature, therefore, I picked Lucentis as the treatment. I also identified the alternative treatment, photodynamic therapy, as an alternative treatment.
Lastly, we have to account for treatment burden and the possible side effects of intravitreal injections. There is a monthly or an as needed approach to intravitreal injections and a large randomized controlled trial showed that both approaches are efficacious with a small benefit from monthly injections. Given that patients must come at least every 6-8 weeks, and likely monthly, to get the visual improvement, we included treatment burden in the secondary statistics as a negative to the treatment. The dreaded complication of intravitreal injections is endophthalmitis and severe ocular inflammation. In the largest retrospective trial I could find, the rate was about 0.85/1000 injections. While a rare complication, we included it in the secondary statistics because of the gravity of the side effect.
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DISCLAIMERS: You must consult your own licensed physician, or other licensed medical professional, for diagnosis, treatment, and for the interpretation of all medical statistics including Treatment Scores. Treatment Scores are for educational purposes only. Treatment Scores may be incomplete, inaccurate, harmful, or even cause death if used for treatment instead of consulting a licensed medical professional. No medical advice is being given. We DO NOT CLAIM to cure, treat, or prevent any illness or condition. Nor do our services provide medical advice or constitute a physician patient relationship. Contact a physician or other medical professional if you suspect that you are ill. Call emergency services (call 911 if available) or go to the nearest emergency room if an emergency is suspected. We are not responsible for any delays in care from using our website, our services, or for any other reason. We are not responsible for any consequential damages of any nature whatsoever. We make no warranties of any kind in connection with our writings or the use of TreatmentScoresBlog.com or TreatmentScores.com. Treatment Scores are about what happened to patients studied in the past; they do not predict the future.
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Patient Power: Problems That Treatment Scores Solve
Patients and doctors don’t understand treatments. There are 130 treatments for insomnia. There are 18,147 papers on insomnia indexed on Medline. How many physicians carry all that medical information in their head? How many people know how effective each treatment is on a one-hundred-point scale? The Patient-Centered Outcomes Research (PCORI) team says, “Every day, patients and their caregivers are faced with crucial health care decisions while lacking key information that they need.”
We have created the Treatment Score Calculator™, which allows the physician and patient to see the main statistic and the secondary statistics. This enables the patient and physician to discuss the treatment along with the side effects so that they can, together, do true shared decision-making. It is vitally important that the patient understands the potential benefit of a treatment, and it’s also vitally important that the patient can have input regarding the side effects of a treatment.
Problems Solved:
- Treatment Scores save money
- Treatment Scores save time
- Patient empowerment/patient engagement
- The previously unsolvable treatment transparency problem
- Personalized medicine
- Patient safety
- The previously unsolvable quality assurance problem
- Continuing medical education
- Solves medical discovery to medical adoption taking 17 years
- Physicians not doing evidence-based medicine
Treatment Scores save money
Treatment Scores save time
Patient empowerment/patient engagement
The previously unsolvable “treatment transparency” problem
Personalized medicine
Patient safety
The previously unsolvable quality assurance problem
Continuing medical education that matters
Solves medical discovery to medical adoption taking 17 years
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DISCLAIMERS: You must consult your own licensed physician, or other licensed medical professional, for diagnosis, treatment, and for the interpretation of all medical statistics including Treatment Scores. Treatment Scores are for educational purposes only. Treatment Scores may be incomplete, inaccurate, harmful, or even cause death if used for treatment instead of consulting a licensed medical professional. No medical advice is being given. We DO NOT CLAIM to cure, treat, or prevent any illness or condition. Nor do our services provide medical advice or constitute a physician patient relationship. Contact a physician or other medical professional if you suspect that you are ill. Call emergency services (call 911 if available) or go to the nearest emergency room if an emergency is suspected. We are not responsible for any delays in care from using our website, our services, or for any other reason. We are not responsible for any consequential damages of any nature whatsoever. We make no warranties of any kind in connection with our writings or the use of TreatmentScoresBlog.com or TreatmentScores.com. Treatment Scores are about what happened to patients studied in the past; they do not predict the future.
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New Treatments for Back Pain
Back pain is a leading cause of chronic pain in the United States. There are many reasons that people have low back pain, but there are not many effective treatments out there. Part of the reason for this is that the scientific community does not understand the mechanism of low back pain. Another reason is that there are some types of pain, such as diskogenic pain, that does not have any current good treatments. There is presently lots of research being done on new, innovative therapies for the treatment of low back pain.
One such treatment, platelet-rich plasma (PRP) is currently being studied. In this, physicians draw your own blood and centrifuge out the platelets. They then take your own platelets and inject them into the areas of pain. One such study that was performed recently evaluated the effectiveness of PRP injections directly into the vertebral disks, for the treatment of diskogenic low back pain. The patients were evaluated at 8 weeks, 6 months and 1 year following treatment. The results are promising and showed improvement in both patient function and perceived level of pain post injection.Despite knowing this information, the study, itself, needs to be rated. How do we know that the study done on the patients was actually a good study? Well, as you can see below, via the Star™ block, that this study gets an overall "B" rating.
Even though this was a double blind, randomized control study, this study's rating declines due to the limited number of patients and the short follow up time period.
It is essential, when evaluating articles, that all of these things are taken into account when making treatment-based decisions. Though this is not the only thing one must take into account, these are some of the important things that we at treatment scores are quantifying to help physicians and patients have a better understanding of which treatment may be the most effective for their disease. (Be sure to read the disclaimers below.)
Treatments to Prevent Death. Do You Want to Live Longer?
Bob wants to live longer! In fact, he never wants to die, especially if he can continue to be healthy. What are the treatments to prevent death? What can you do to increase your lifespan? Statistically speaking, what can you do to increase your overall survival?
Let me show you how personalized medicine, evidence-based medicine, and shared decision-making can actually work together. Let me show you the future of medicine: Treatment Scores.Bob is a 62-year-old man. He is at the stage of life where he is reading the obituaries, because friends and acquaintances are dying every year. Bob has no diseases, but he has heard that lifestyle changes might make you live longer, and he has seen some of the headlines about “longevity pills.” He reads anti-aging magazines.
Like Bob, you may have seen this headline: “World’s first anti-ageing drug could see humans live to 120.” They were talking about metformin. Metformin is a medication usually used for type II diabetes patients. There is a study going on called: “Targeting Aging with Metformin (TAME).” The purpose of the study it is to see if healthy people without diabetes given metformin will live longer than a control group.
Why is there so much excitement about metformin (trade name Glucophage)? In one study, patients with type II diabetes on metformin actually had an increased overall survival rate compared to a matched control group. Some researchers also made the assumption that the diabetes type II group should have died off at a significantly higher rate than those without diabetes, because that is what usually happens according to some studies.
The problem is that there has never been a randomized controlled trial comparing people without type II diabetes who take metformin with those who don’t take metformin. The assumption that metformin may be a “fountain of youth” drug is based on making assumptions from less-than-perfect studies. Nevertheless, it’s a worthwhile hypothesis. It needs to be studied further. That’s why they are doing the “Targeting Aging with Metformin (TAME)” study.
Additional reasons to consider metformin as an antiaging drug are that metformin extended the life-span of worms and also extended the life-span of mice. However, animal studies often don’t translate when human studies are done. Sadly, there is a long history of drugs working in animals that end up not working in human beings. Yet, sometimes they do work.
Let’s look at three “treatments to prevent death” and see where they stand based on the studies that exist. When it comes to metformin we want to know what the actual human studies say. We want to know the human evidence, the clinical evidence, right now.
Our diagnosis is “death” and our treatments are “treatments to prevent death.”
I went to the medical literature and looked up studies on metformin. I found the studies that I thought were most important for figuring out the increase in overall survival for 62-year-old people without diabetes who take metformin. Then I created a Treatment Score using our Treatment Score Analyzer™ software to represent metformin as a treatment to extend life.
I came up with a Treatment Score of 0.1 for metformin. How did I come up with this number? What I’m about to show you next is the future of medicine. It is the Treatment Score Calculator™, which is the device that will allow for shared decision-making to happen between physicians and patients.
Below is our prototype Treatment Score Calculator™ of what the future will look like.
It’s simple. The main statistic is at the top left. The secondary statistics are on the right. When you "weight" and subtract the secondary statistics from the main statistic you come up with the Treatment Score in the bottom left. In this case, there were a lot of negative side effects, so the Treatment Score was reduced from 0.6 to 0.1.
Physicians will have to show you the numbers, and as a patient, you will have input on how to "weight" the numbers, especially the side effects and the side benefits on the right.
So metformin currently has a very low Treatment Score according to the data that I’ve seen. Let’s compare this to some other things. Let’s look at two lifestyle issues “never smoking” and “stopping smoking.”
What does this tell you? The Treatment Score for being a 62-year-old person and never smoking is 20, the Treatment Score for being a 62-year-old person and stopping smoking is 6.7, and the Treatment Score for metformin according to the studies we have right now is 0.1.
Bob needs to know that the medical literature suggests that he should never smoke, that he should stop smoking if he does smoke, and that metformin has a such a low Treatment Score (and it might be even lower because I didn’t score some of the side effects) that he should probably wait for the results of the metformin randomized controlled trial, in which I hope metformin turns out to be a significant life extender!
This is the future of medicine. Treatments will be presented to you in lists, and those treatments will have Treatment Scores which represent the evidence-based medicine that currently exists behind those treatments.
Treatment Scores will empower patients. They will greatly increase patient safety. They will combine personalized medicine, evidence-based medicine, quantification, and shared decision-making for the first time in medical history.
The genius, Albert Einstein, said this: "If you can't explain it simply, you don't understand it well enough."
I believe this suggests that if you can’t explain treatments simply with Treatment Scores, then you don’t understand treatments well enough. There is proof that this is a huge problem today. Here is a study that proves physicians do not understand treatments well enough: “Do clinicians understand the size of treatment effects? A randomized survey across 8 countries.” http://www.cmaj.ca/content/early/2015/10/26/cmaj.150430
It’s not the physicians’ fault by the way, it’s because they have never had the training or the tools they needed before. Once physicians understand treatments, they can explain them to patients much better, and there can be true shared decision-making.
Finally, if you understand economics, you should be able to predict that Treatment Scores will improve everything in medicine: education, informed consent, consumer engagement, treatment transparency, patient safety, patient choice, research, healthcare distribution, and reimbursement. (See the disclaimers below.)
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DISCLAIMERS: You must consult your own licensed physician, or other licensed medical professional, for diagnosis, treatment, and for the interpretation of all medical statistics including Treatment Scores. Treatment Scores are for educational purposes only. Treatment Scores may be incomplete, inaccurate, harmful, or even cause death if used for treatment instead of consulting a licensed medical professional. No medical advice is being given. We DO NOT CLAIM to cure, treat, or prevent any illness or condition. Nor do our services provide medical advice or constitute a physician patient relationship. Contact a physician or other medical professional if you suspect that you are ill. Call emergency services (call 911 if available) or go to the nearest emergency room if an emergency is suspected. We are not responsible for any delays in care from using our website, our services, or for any other reason. We are not responsible for any consequential damages of any nature whatsoever. We make no warranties of any kind in connection with our writings or the use of TreatmentScoresBlog.com or TreatmentScores.com. Treatment Scores are about what happened to patients studied in the past; they do not predict the future.
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Copyright © 2016 Treatment Scores, Inc.
NFL player Chad Johnson’s Urine Treatment for Sprained Ankles (Ochocinco)
Former NFL football player Chad Johnson (Ochocinco) treated his ankle sprains with urine. He would actually get donations of urine from other NFL players. Chad revealed this treatment on the ESPN television show Mike & Mike.
Is soaking your sprained ankle in urine a valid treatment? What does the medical literature say?
Chad Johnson, by the way, was a wide receiver in the National Football League. He played for the Cincinnati Bengals and the New England Patriots. He was an outstanding player and made the Pro Bowl many times. When he wore number 85, he acquired the nickname Ochocinco, and legally changed his name to Chad Ochocinco before eventually changing it back to Chad Johnson.
I have come up with a list of treatments for a sprained ankle by researching the medical literature. I will study the treatment benefit for all of these treatments using our new technology called the Treatment Score Analyzer™, and will produce Treatment Scores.
Treatment List:
1. crutches until free of pain
2. rest
3. ice
4. elevation
5. heat
6. urine soaks (the Chad Johnson, Ochocinco, method)
7. contrast baths (alternating hot and cold)
Let’s begin with the Chad Johnson method of soaking a sprained ankle in warm urine collected from other people. I went to Medline and searched every combination of “sprained ankle,” “ankle sprain,” “ankle swelling,” and “urine” that I could imagine. How many clinical studies did I find for this urine treatment? Zilch, nada, none.
This means that “warm urine baths” for treating a sprained ankle has a Treatment Score of zero, or even more accurately “no data,” because there are no studies.
Is there any reason to think that soaking your sprained ankle in urine would be beneficial? Is there something in urine that might be absorbed through the skin that would be beneficial to a sprained ankle? Does urine, because it can be hypertonic, pull something out of a swollen ankle that might be beneficial? I could find nothing. It’s a hypothesis with basically no clinical evidence to support it at this time.
Did Chad Johnson feel better? I sent him the following tweet: “@ochocinco Chad, do you believe that soaking your sprained ankles in warm urine worked? Did your ankle feel better after such treatment?”
The way medical science works is that you do a case report, do better studies, and eventually do a randomized controlled trial to remove all biases and get at the most objective truth possible.
If Chad Johnson believes treating a sprained ankle by soaking it in warm urine works, he should help see that a proper study gets done. Who knows what a study would show? That’s why we do studies.
The bottom line is that the Treatment Score = 0 for treating a sprained ankle by soaking it in warm urine. Or, perhaps more accurately the Treatment Score = no data, because no clinical studies have been done.
The future of medicine has arrived. It is no longer good enough to talk about treatments without quantification with Treatment Scores. Our website tools are at TreatmentScores.com. Our blog is here at TreatmentScoresBlog.com. If you are a health writer, or health blogger, who wants to write evidence-based medicine articles with quantification, please contact Dr.Hennenfent [(at)] Gmail.com.
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DISCLAIMERS: You must consult your own licensed physician, or other licensed medical professional, for diagnosis, treatment, and for the interpretation of all medical statistics including Treatment Scores. Treatment Scores are for educational purposes only. Treatment Scores may be incomplete, inaccurate, harmful, or even cause death if used for treatment instead of consulting a licensed medical professional. No medical advice is being given. We DO NOT CLAIM to cure, treat, or prevent any illness or condition. Nor do our services provide medical advice or constitute a physician patient relationship. Contact a physician or other medical professional if you suspect that you are ill. Call emergency services (call 911 if available) or go to the nearest emergency room if an emergency is suspected. We are not responsible for any delays in care from using our website, our services, or for any other reason. We are not responsible for any consequential damages of any nature whatsoever. We make no warranties of any kind in connection with our writings or the use of TreatmentScoresBlog.com or TreatmentScores.com. Treatment Scores are about what happened to patients studied in the past; they do not predict the future.
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Sources:
Chad Johnson, Mike & Mike, television show, February 10th, 2016. http://www.foxsports.com/nfl/story/chad-johnson-ochocinco-warm-urine-ankle-sprains-021016
Wikipedia
https://en.wikipedia.org/wiki/Chad_Johnson
Chad Johnson Biography
http://www.jockbio.com/Bios/ChadJ/ChadJ_bio.html
Regenerative Therapies for Knee Osteoarthritis
At TreatmentScores.com, the physicians and staff aim to quantify medical facts into one website of unbiased, evidence based information. Recently, I have been researching the up and coming field of regenerative medicine. As seen in the STAR™ Blocks below, osteoarthritis is being treated with PRP, exercise and adipose derived stem cells.
From the statistic above, we can see that exercise, PRP and stem cells all significantly improve the patient's pain, function, and quality of life. However, using the Treatment Score Calculator™, the total score for the study, as seen below, only rates the overall study at a 50. This is because we must take into account, not only the study's outcome, but also how the study was performed, the number of patients in the study, and the overall relevance of the study to the actual outcome of the study.
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You must consult your own licensed physician, or other licensed medical professional, for diagnosis, treatment, and for the interpretation of all medical statistics including SOM® Treatment Scores. Treatment Scores are for educational purposes only. Treatment Scores may be incomplete, inaccurate, harmful, or even cause death if used for treatment instead of consulting a licensed medical professional. No medical advice is being given. We DO NOT CLAIM to cure, treat, or prevent any illness or condition. Nor do our services provide medical advice or constitute a physician patient relationship. Contact a physician or other medical professional if you suspect that you are ill. Call emergency services (call 911 if available) or go to the nearest emergency room if an emergency is suspected. We are not responsible for any delays in care from using our website, our services, or for any other reason. We are not responsible for any consequential damages of any nature whatsoever. We make no warranties of any kind in connection with our writings or the use of TreatmentScoresBlog.com or TreatmentScores.com. Treatment Scores are about what happened in the past they do not predict the future.
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Copyright © 2015 Treatment Scores, Inc.